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Estimate/calculate power for two-sample Mendelian randomization?

Dear All,

There are several websites that allow calculating power for one-sample MR study, such as https://sb452.shinyapps.io/power. Yet, I couldn't find any to estimate power for two-sample MR. I appreciate if anyone could help either in the link, the formula or any guide.

Thank you and look forward to receiving your attention and help.

mr

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