Hello,
I am working on spatial transcriptomics and I would like to do deconvolution using SPOTlight, in the tutorial they use mean.AUC but I would like to use logFC. There are two different logFC available in my data: logFC.detected
and logFC.cohen
. Which one is the most relevant? How to determine the threshold to use?
In the tutorial, to keep only those genes that are relevant for each cell identity a filter is used for relevant marker genes, those with AUC > 0.8 are kept
I never heard about logFC cohen before and I don't find documentation about it, if someone can help me please do.
I hope you can understand what I explained, English is not my language