Hello,

I was wondering if people might talk about their take on merging Hi-C data from different samples that are the same biologically (e.g. the same cell line treated equivalently) but the experiments were performed using different restriction enzymes (e.g. one is HindII and the other one is the arima strategy, HinfI + DpnII).

Has anyone merged for example at the *.allValidPairs stage of HiC-Pro to create one single matrix?

Thanks!