Polygenic risk score percentile cutoff
Dear everyone,
I working on PRS using information from PGS catalogue, however my data from illumina infinium GDA was not covered all SNP in each PGS catalogue just only 10-20%.
I would like to know that which percentile should I use as cutoff from Z score in PRS plot.
Edgar
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UnivStudent
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endoplasmicreticulum12 •
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endoplasmicreticulum12 •
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Hi Edgar, you need to use imputation to use the genotyped to get better coverage of the SNPs in the genome. Usually people use an imputation server like Michigan (https://imputationserver.sph.umich.edu) or TopMed (https://topmedimpute.readthedocs.io/en/latest/) for this.
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