RnBeads mean difference vs M-values
Hello all,
Please excuse if this is a beginner question.
Could anyone advise as to how to interpret differential methylation analysis results from RnBeads? I see they calculate a mean-mean difference for each site, but when I review other papers the statistics are reported in terms of an M-value.
Does anyone have any insight into this?
Thanks!
• 1,090 views
•
link
updated
by
Basti •
•
written
by
a.basitkhan1990 •
•
written
by
a.basitkhan1990 •
1 answer
Follows S.O.P's
• 0 views
•
link
written
by
acarrillofuentes67 •
Log in to answer this question.
More posts like this
-
Why do I get a big log fold change but small mean change in b value when plotting differential meth…
written by Christine •
-
Code for simulation of data sets
written by lorenzo •
-
Multifactor analysis in DESeq2
written by a.basitkhan1990 •
-
"MethylKit" package for WGBS data
written by shrinka.genetics •
-
Filtering & validation strategies for methylation analysis without normal controls
written by Mathias
-
Interpreting level-3 TCGA methylseq data
written by mforde84
-
Human 450K methylation data analysis for DMP
written by halo22
-
considerations for epiallele studies (DNA methylation Bisulfite Sequencing)
written by reilly.brian.m
-
RnBeads and beta-value matrix data format
written by areyoujokingme •
-
Understanding miRdeep2 mapper output
written by niu2rseq
M-value is log2(beta/(1 - beta)). M-values are usually used to perform statistical calculations because they are homoscedastic, contrary to beta values which are intended to visualization.