If you use NCBI ClinVar XML files for your application or analytical pipeline, you may need to make changes to your tool or pipeline code by 2024 because we will be significantly updating ClinVar’s XML format to support new somatic variation data.

To prepare for these changes, please preview the submission spreadsheet templates, updated XSDs, sample XMLs, and supporting documentation on GitHub. Once the new XML format is available, we will continue to support the old XML format through the end of 2023. However, we encourage you to start the transition to the new XML format as soon as you can.

See our post on NCBI Insights for more information.