Normalization of NGS data to make CNV calls
Hi Community,
I have WGS dataset for 4 disease and 4 controls samples. I have computed the coverages for analysis CNV (GATK procedure). However, some samples seem to have more variation than other so I think it is essential to do normalization among samples.
I would like to ask which kind of normalization method should I perform? And any suggestion for package that I could use?
Bests,
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