Integrating single-nucleus RNA-seq and single-cell RNA-seq datasets
Hi all,
I am looking to integrate several scRNAseq datasets with a snRNAseq dataset.
What are thoughts on integrating datasets from these 2 different modalities? Is it feasible/worth trying, or is it likely to do it poorly?
Would appreciate it if you could reference some publications that compare the results of the integration.
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What do you want to do with the data once you integrate it?
Standard stuff: e.g. compare DEGs between clusters and differential abundance analysis between 2 conditions.