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How Wald test calculates p-values in DESeq2?

How Wald test calculates p-values in DESeq2?

After getting (LFC) Log2foldChange how p-values are calculated for each gene in samples by Wald test? by results function we get p-values how they are calculated ?

Thanks

wald p-value deseq2
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written by Amr • Amr

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The answer will be the z-test for two samples:

z = ( ¯x1 − ¯x2) -D / √σ1^2/n1 + σ2^2/n2)

Where ¯x1 is the mean from the collected cancer samples and ¯x2 is the mean of the collected normal samples.

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written by Amr • Amr

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