Low number of differentially expressed genes in scRNAseq
I generated a list of DE genes (p-value < 0.05 and |LFC| > 0), the result shows only 8 upregulated genes which I think is a low number. My question is, can this low number of DEGs between two conditions in scRNAseq represent anything? If yes, what?
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That is impossible to answer without more context on the experiment and the DE strategy you used.
It depends obviously on multiple things for example the way reads are mapped and handled as well as the experiment design. As @ATpoint mentioned more information is needed to address your concern.