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Log-Transformed Upper-Quantile Normalization for RNA-seq Counts

Dear all, My goal is to perform Log-Transformed Upper-Quantile Normalization on RNA-seq data. And then do Linear Regression (LASSO). I would appreciate it if anyone could tell me what tool or server I should use for each part?

regression normalization rna-seq

Do you have knowledge of R or any other language or does it need to be click&do / GUI solution?

I'm familiar with R and Python, but I'd rather use a simpler solution. I'd appreciate any suggestions you may have.

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