Copy Number to Log2_ratio for autosomal

Hi,

I want to transform some ASCAT data into log2_r values. The file contains at total copy number column. I would then take fold ratio of the total copy number versus the natural ploidy, correct? Can I assume the natural ploidy for all autosomal regions are 2?

Thanks!

gdc cna cnv autosomal

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updated 4.7 years ago by Zhenyu Zhang

• written 4.8 years ago by afollette •

1 answer

I am confused on what you want to do. If you want to compare to diploid of 2, why don't use the ASCAT copy number directly? I missed the point of log2 transformation and what you expect to gain from this.

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written 4.7 years ago by Zhenyu Zhang

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