Biosynthetic gene clusters
Hello everyone!
I would like to ask for help/advice regarding my methods. I have a metagenome data that I have assembled using metaspades, binned using metabat2, and annotated using Prokka. I only extracted specific genera of bacteria from the metadata. I wanted to analyze the biosynthetic gene clusters of these MAGs. I used anti-smash and Bagel4 for this but my question is.. How can I tell if a BGC have antiviral potential without the need of in vitro analysis?
The results I got from anti-smash looks like this (attached photo). Thank you very much! I hope you can help me.
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You can tell only if the product of reference cluster:
Most similar known clusterhas known antiviral activityThank you for your reply, sir.
How about the BGCs without hits to Most similar known cluster?
The only thing you can do is a literature search using the
Typename: i.e. "lasso peptide" AND "antiviral".Thank you so much, sir!