how to figure out if multiple benign mutations in one gene are harmful together?
I have found three coding mutations in one gene among my target population. I used three different softwares (polyphen2, sift, provean) to see how harmful these mutations are. all of them suggested that each of these mutations are not harmful (benign or neutral) on their own. but non of them showed any info about harmfulness of all of these mutations together. Is there any way to get these softwares to tell me how bad all these mutations are together for this gene? or would you please suggest any other software to figure that out?
0 answers
No answers yet.
Log in to answer this question.
More posts like this
-
How to determine if a somatic mutation alters transcription factor binding site?
written by ConvolutedGenome •
-
Physical interaction of long non-coding RNAs with target genes
written by seta
-
What is REF and ALT ? Does all variations are mutations ?
written by sofie_carolina •
-
Download or subset pathogenic variants for a selected gene from ensembl
written by victor.lorca.castellanos •
-
SNP IDs that are not being recognized by SIFT website
written by mahdikhadem95 •
-
Interpretation of Eigenstrat results
written by kelly.wang135
-
Annovar - SIFT prediction: Multiple transcripts, which transcript is used for scoring?
written by vw •
-
Is It Nonsense To Have Sift/Polyphen2 Scores For Nonsense Variants ?
written by Raony Guimarães
-
Stop-Gain Mutation Predicted As Benign By Sift/Polyphen2?
written by michealsmith
-
Analysis Of Putative Causitive Mutations
written by Kamila001
