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How to perform principal component analysis (PCA) on topologically associating domain (TAD) data?

The TAD data may like this:

chr3    19919999    20259998    
chr3    19919999    20259998
chr6    52539999    52939998
chr17   67819999    68159998
chr6    71719999    72079998
......

And this file ends with ".bed"

tad pca

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