Regarding p53 (tumour suppressor gene) mutation and overexpression relation with survival analysis
Hello everyone Can anyone tell that how p53 mutation and overexpression is calculated for survival analysis in tcga data..
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jyotsnap •
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I actually think that the mechanism for cancerogenesis is loss-of-function of TP53 which leads to decreased, not over- expression.
yes but extent of p53 mutation is different in different types of cancer, thats why some cancers are P53-wildtype cancers (where its expression is higher) while some are P53-mutated cancers (where its expression is lower)