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what is the best tool to remove PCR duplicates from miRNA seq without UMI?

I am not sure about the tools that can process PCR duplicates in miRNA-Seq data. Most of the posts I have read were related to UMI.

I am also not sure if we need to remove the duplicates. Since I was following the deduplication step with UMI indexed samples, i was wondering if we need to do the same without UMI.

Thanks for the help

mirna-seq sequencing

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