PSSM from alignment

Question

[Vladimir Leshuk]

Can you please suggest web applications or packages for R/Python, that don't use PSI-Blast and make PSSM directly from an alignment file? Thanks in advance.

[Dunois]

Here's a possible solution in python. As far as I know, there aren't any good packages for this purpose in R.

Answer 1

[Mensur Dlakic]

Haven't tried the service below because I don't know why anyone would use something other than PSI-BLAST for this task, but here goes:

https://fasta.bioch.virginia.edu/fasta_www2/chaps.cgi

[Vladimir Leshuk]

Thank you!