Hello,

I am using rvtest to perform a burden analysis from a VCF. Yet, I get the error core dumped: Segmentaion fault . Iasked on rvtest github what might be the cause of the error but got no answer (https://github.com/zhanxw/rvtests/issues/119).

The command I ran is the following:

rvtest --inVcf input.vcf --pheno phenotype.ped --out output --geneFile refFlat_hg19.txt.gz --burden cmc --vt price --kernel skato,kbac.

I tried to do a traceback of the error and got the following message:

I since noticed that, when I do not annot my VCF file with Snpeff, the error does not occur. Therefore I tried to remove the 'ANN' tag added to the VCF by Snpeff, but the error persits.

Thanks in advance!