Hi,,
Can anyone recommend/suggest an approach that I can use to integrate the mRNA expression data with chipseq data to understand how the epigenetic profiles changes from primary and recurrent samples. So, I have TSS expression data and a chips data. I post-processed the chips data and I apply ChromHMM to get the chromatin state across the samples. I would like to know how can I used these data to find the pattern of histone modification changes across cells and how can I correlate this with mRNA expression data.
Thanks,,
Muna