How To Validate A Translocation Has Happened By Computing
Recently, I am calling translocations from the whole genome sequencing data by using DELLY. But it reports many results, so How to validate a translocation has happened by computing. Does anyone have a good idea？thanks !
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Michael Dondrup
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siyu •
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siyu •
2 answers
If you want a second computational method for this, BreakDancer calls structural variations like translocations. But depending what you want to do with this knowledge, at some point you probably should prove it with a karyotype and some FISH probes.
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Alex Paciorkowski
Perhaps you could do a de novo assembly and see which of your predicted translocations are present in the assembly.
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Mikael Huss
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