Direction And Sign Of Interaction In Protein-Protein Interactions
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can you please describe what are "direction" (location?) and "sign"(regulation?) ?
by direction I mean if P1 interacts with P2 or vice versa.
I suppose, most databases are capable of doing so. For example, turning on the 'actions view' in the STRING database (http://string-db.org) provides such information if it's available, e.g. http://string-db.org/newstring_cgi/show_network_section.pl?taskId=Woo70GUVtvhc&interactive=yes&network_flavor=actions
thanks a lot. It is exactly what I was looking for.
To clarify these comments. It rather depends how you define "interaction".
If protein A is known to act upon protein B in some regulatory manner, then that interaction could be said to have a direction and a sign. However, where interaction simply means "is physically associated with", as in many PPI databases, then that is modelled as an undirected graph.