Databases For Gene Family?
3
4
Entering edit mode
13.1 years ago
Dejian ★ 1.3k

I have got some lists of gene families. For example, list1 and list2. I'd like to know whether there are some databases recording genes that can form gene families in genome.

gene database • 7.5k views
ADD COMMENT
7
Entering edit mode
13.1 years ago

I would start at TreeFam: http://www.treefam.org/

ADD COMMENT
6
Entering edit mode

Treefam is dead, for now. If you want to find the latest gene build, you will be disappointed (if you do not care, treefam is still fairly good IMO). The treefam pipeline has been largely adopted and improved by EnsemblCompara.

ADD REPLY
1
Entering edit mode

Update: Treefam is reborn and a new release is coming. The Pfam/Rfam group at Sanger has taken it over.

ADD REPLY
0
Entering edit mode

Pretty good. "The ultimate goal of TreeFam is to present a curated resource for all the families." I think this db will be a good help to me. Thank you, Chris.

ADD REPLY
0
Entering edit mode

Treefam is dead, for now. If you want to find the latest gene build, you will be disappointed. The treefam pipeline has been largely adopted and improved by EnsemblCompara.

ADD REPLY
6
Entering edit mode
13.1 years ago

Ensembl has excellent gene family calculations. Check out the family of ensembl databases here if you are not looking at vertebrate model organisms. biomart provides query access to most of these if needed

ADD COMMENT
5
Entering edit mode
13.1 years ago

Of course, part of what drives where you search and is what you're looking for. I know of two excellent database for cytochrome P450 (basically xenobiotic and drug metabolizing enzymes) genes, one of which has a focus on gene variants and implications in drug treatment/dose. This means, you may need to search the literature for "gene family" + "database." Or similarly search the internet.

Added in edit on 16 Feb 2012: In looking closely at the UniProtKB entry for human albumin, P02768, I see that there is listed in the COMMENT field: [WEB RESOURCE] Name=Albumin Website; URL='http://www.albumin.org'. This could be an approach to identify if there is a database for a gene family of interest. Find the protein in UniProtKB and scan this COMMENT field.

ADD COMMENT
0
Entering edit mode

Many thanks. One of my colleagues is going to work on p450. I have forwarded this message to her. :)

ADD REPLY
0
Entering edit mode

Several P450 subfamilies from treefam. The nice thing about treefam is you see trees.

ADD REPLY

Login before adding your answer.

Traffic: 3033 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6