Hello, I have some interesting genes identified in my exome samples, and would like to check their oligogenic effect and also make STRING test. I have only one phenotype of interest. I found nice database - Toppgene, but got confused, what of provided options can I use there. I have two types of gene lists: 1) genes with clear evidence on particular phenotype; 2) genes that can be related with this phenotype, but with low evidence level. I filtered probably pathogenic variants from both of these lists. How should I implement STRING test in such case? Can anybody explain to a newbie, how to use Toppgene and machine learning with exome data?

Thank you!