Hello,

I plan on using Mutect2 to call somatic variants for WGS. The alignment and sorting is already performed by the core facility, which uses the GRCh37.p13 reference genome. For optimal performance a panel of normals should be used when running Mutect2, however as far as I know there is no publicly available panel of normals for the GRCh37. However, there is a panel of normals for b37. I was wondering if you think, that I can take this panel of normal, regardless of the slight differences in the reference genome.

Cheers!