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Measuring heritability of variant in a family based study

Hi!

I am analyzing whole exome sequencing data in a family with a complex disorder. Through a set of filters I have arrived at a set of SNPs (filters based on certain genes of interest).

I would like to quantify the heritability of these polymorphisms by calculating the h2 values.

How can I do that in such non-GWAS based setting.

Help is appreciated!

snp heritability

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