I also think that they have a regularly updated local abstract repository and searching in GOPubMed retrieves large document sets (more than 1M documents for "DNA") in short response time, which might not be entirely possbile using e-utiilies.
How To Choose The Right Way Of Data Mining From Pubmed?
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It seems that this service works by making use of the public data dumps from NCBI that are then parsed, analyzed and categorized into their own data models and databases and then queried with their own proprietary tools and methods.
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I agree with Sundeep adn Istvan Albert. However, once bulk of information is processed on data dumps, for daily updates using eutils should be practical.
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I use eutils a lot for my work.
http://www.ncbi.nlm.nih.gov/books/NBK25501/
They are pretty flexible and easy to use and you can do almost anything using them. The result or output generated for a query is in XML format and you can write your own parser or used XML parser in BioPython or BioPerl.
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