The Extended Sam: The Symbols '=' And 'X' Vs 'M'
For visual inspection of alignments, it would be easier for tools like BWA to use the extended version of the format http://samtools.sourceforge.net/SAM1.pdf. The new version differentiates between matches and substitutions.
So far for both matches and mismatches the same symbol 'M' is used. Any rationale behind this?
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Possible duplicate of http://www.biostars.org/post/show/17043/should-we-attempt-to-redefine-the-cigar-string-in-sambam-format/
Ah, excellent point. You can safely close this thread.