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Is this a normal mean/variance scRNA plot?

I've been following bioconductor's OSCA book for some scRNAseq analysis (smart seq2 protocol, no spike-in). After QC, normalization (deconvolution) and transformation (log2, pseudocount 1) upon plotting the mean/variance of the genes, I noticed that the plot looked very much like a negative parabola: mean_var

This isn't what I'd seen in the OSCA examples. I was wondering if this is a cause for concern, or if I should continue forward into feature selection.

Thank you for your time! Let me know if I should provide any more information.

rna-seq r
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updated by Biostar Biostar • written by aaragak1 • aaragak1

Can you share the code please?

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written by ATpoint ATpoint

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