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mediation analysis in twin samples

Hi!Everyone!

Which method should I choose or is there a suitable method for mediation analysis in twin smaple?

Now I have used the SNP genotype for X, image phenotype for M, the cognitive phenotype for Y.

I tried to use SPSS process 3.0 module 4 to compute mediation analysis in the above relationship. But accounting for my samples are non-independent individuals (twin sample), I want to know if there is a mediation method for this sample type or must I divided samples to independent individual.

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