It says that port 4444-4544 are not accessible. Ports can be considered as channels through which your computer accepts data. In this case, the blast program needs to use port number 4444 and 4544.

I guess this error could be caused by two things: 1) some other software is using those ports or 2) it's blocked in your network. If you're on a campus/office network, you can perhaps ask the IT guy see which one it is and to try fix it.