Hi there,

I need to perform a stress test in a GWAS tool and the duty demands a dataset (plink format) having 100 thousand samples, having 40 million SNPs in a proportion of case:control=30:70.

I'm performing the command:

plink1.9 --simulate ds1.sim --make-bed --out ds1 --simulate-ncases 30000 --simulate-ncontrols 70000

But after about 3 hours execution, I'm facing Error: File write failure., even though my environment has 256T of disk. (It's a container with a S3 (Object store) mounted through s3fs).

I was wondering if there's a clever way to do that? Perhaps breaking it into small chunks and merging up later somehow? It would prevent me to be waiting hours till a error happens and I loose either time and the sample generated so far.

Thanks in advance!