Calculate LOH score for tumor only sample using GenomeStudio

Question

[kspata]

Greetings,

I wish to calculate LOH sores of around 80 tumor only samples using GenomeStudio. In the Analysis tab of genome studio I can see paired sample analysis, but my samples are tumor only samples and don't have corresponding reference samples.

How can I calculate LOH scores for tumor only samples? I have the InfiniumOmni2-5-8v1-5_A1_ClusterFile.egt culster file. How can I use this as a reference to calculate LOH score?

I watched a webinar in this link: https://illuminasupport.webex.com/illuminasupport/lsr.php?RCID=e4fe2520a7e3eb957b60cf9082c40fde which only explains how to calculate CNV scores.

Thanks in advance !!