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MERLIN: MIBD estimation

Hi,

I have doubts about how I should estimate the Multipoint Identity By Descent using MERLIN.

  1. How many SNP should I analyse per window? In other words, How can I determine the lengths of the locations (in Cm) I analyze?

  2. Which threshold of LD do you recommend between SNP?

  3. I have "large" pedigrees. The bigger one, in terms of MERLIN, occupies 65 bits (individuals). Should I use MERLIN or do you recommend another software? (Most of the pedigrees are +- 30 individuals).

Could anyone give me a hand?

merlin mibd ibd linkage analysis

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