What is the relationship between structural variants and fusion genes? Is a fusion gene caused by a structural variant? For example, a deletion happens where the region between two genes is removed then two genes are fused. What about other SVs?
1 answer
I think this article abstract answers your question. All fusions are structural variations, as far as I have understood, but not
visa versa. There are a lot of other kinds of structural variations, see WIKI-link at the bottom.
https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-018-1421-5
"Transcripts are frequently modified by structural variations, which lead to fused transcripts of either multiple genes,known as a fusion gene, or a gene and a previously non-transcribed sequence."
https://en.wikipedia.org/wiki/Structural_variation_in_the_human_genome
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