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Given that you do not any details I suggest you search PubMed for recent benchmarking papers e.g. this one from a colleague of mine, which she published very recently: https://www.ncbi.nlm.nih.gov/pubmed/31134276
Thanks for your suggestion. I read that paper and tried to use Splinter's methods to do analysis, but their R code is hard to follow. The data I used as input is from pipe4C pipeline. Do you know if there's any explanation of Splinter's code?