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Estimate the genomic relationship between Discovery and Target sample in PRS

Hi everyone,

I am trying to calculate the genomic relationship between discovery and target sample but I am not sure how to make the running time affordable for large sample size (E.g 500k individuals x 1 million SNPs).

Your help is really appreciated!

gwas prs
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updated by Sam Sam • written by landscape95 landscape95

Please explain better the program(s) that you are using, and providing any actual code that you have use would be helpful, too.

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written by Kevin Blighe Kevin Blighe

1 answer

Given your tag and your sample size, are you trying to perform PRS analysis on UK biobank data? You can definitely run an analysis on this sample size using the common PRS software such as PRSice, lassosum and LDpred.

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written by Sam Sam

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