I am doing some analysis about identify the driver mutation, and what tool I choose is MutSigCV, because it is from broadinsititude. But I met some problem:

1. where can I get the detailed about how MutSigCV actually calculates the background mutated rate (BMR)? I wonder if it calculate the rate for each patient or base on the population?

2. As claimed in their website, MutSigCV now support hg18 or hg19 version of genome, so if I have to deal it with hg38, as the most data is based on this version, what sould I do?

Thanks for any suggestion.