Would haplotype analysis is enough for a rare disease?

Question

[nuketbilgen]

Hi, I want to analyze the WGS data from the following work,
- the aim of the project finding a pathogenic variant. - samples are core family (father, mother and two affected offspring) and one nonfamily member. - penetrance is observed in the sample group, (female offspring affected severely and male affected offspring moderately)

Would haplotype analysis is enough for a rare disease? What else do I need?

kind regards.