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There was this thread some time ago, but I dont know how much curation you're hoping for: Top GitHub repos for biomedicine
Querying WoS (web of science) might give some ideas as well though, topic Bioinformatics, limit to last 5 years, order by #citations
using total citation count? that's not really fair to the 2018 articles, is it?
point taken.
then what about avg #citations /year? also not completely 100% fair but nearly I would say.
And all this in the assumption of course you actually have access to Web of Science ;)