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Why? Are we trying to compare populations?
Yes, we are trying to compare populations
Maybe compare distributions instead?
Distributions means? I have SCORESUM (polygenic score values) and i have to test for phenotype enrichment against my phenotype file. How should i do it? Thanks in advance
Perform a standard regression between the phenotype and the SCORESUM, and adjust for any covariates.
Keep in mind that 'polygenic risk score' is a general term and that there are so many ways to derive these. Most methods start from the beta coefficient from the regression fit, i.e., between
phenotype ~ SNPThank you everyone for your valuable responses. Will try it out on the data.