How to merging multiple GSEs with different GPLs?

I want to merging multiple GSEs with different GPLs(with R) ,but I don't know which package is suitable for merging, for this purpose, VirtualArray and InSilicoMerging packages do not efficient.

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written 7.5 years ago by maryam.sabet •

Could you explain what are you trying to do? GPLs describe different GEO platform (Sequencing, array or even RT-PCR) and unless they are measuring similar things, you can not merge them. On the top of that, you need to care about different normalization and overall normalization of merged samples.

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written 7.5 years ago by Santosh Anand

I want to find similar genes between different GPL then compare expression level of these genes to find out which have significant difference.

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written 7.5 years ago by maryam.sabet •

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