Question: How to create BigWig files with normalised signal using ChIP-seq and Input?
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Hello,

I have ChIP-seq and Input, and want to display occupancy normalised by the Input (e.g. input-subtracted, or divided by the Input). is there some solution to create one BigWig file starting from two BAM files with the ChIP-seq and the Input?

Thanks!

ADD COMMENTlinkeditmoderate 13 months ago biostart • 290 • updated 13 months ago Devon Ryan 90k
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You're looking for bamCompare from deepTools, which can create both input-subtracted and signal divided by input tracks.

ADD COMMENTlinkeditmoderate 13 months ago Devon Ryan 90k

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