Find protein residues in PDB file that is the most exposed (and does not influence residues around it as much)

Question

[skim]

I need a technically and logically sound way to find protein residues in PDB file that is the most exposed (and does not influence residues around it as much) by processing the PDB file on a script such as Python.
I know about the solvent accessibility method, but I need to focus on the part that it makes minimal influence residues around it even if it is mutated.
Is DSSP and surface exposure still the best method, or are there any other creative methods for this purpose?