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Tool for computing Tumor Mutational Burden?

Hello,

I know that Tumor Mutational Burden is the 'number of variants per megabase' but, how can I compute this? are there any bcftools or samtools commands or R packages that can obtain this information from the vcf files? I have no idea about this, sorry.

Thank you !

tmb mutation

Hello Pin.Bioinf!

We believe that this post does not fit the main topic of this site.

You already have a thread open for a very similar question (Can I compute Tumour Mutational Burden from rnaseq fastq files? ). For that reason I am going to close this one to keep the discussion in one thread.

For this reason we have closed your question. This allows us to keep the site focused on the topics that the community can help with.

If you disagree please tell us why in a reply below, we'll be happy to talk about it.

Cheers!

Yes, I posted a question asking if this was possible on RNA-Seq, this question is not about RNA-Seq but in general. Nobody told me what tools can be used to do it, and there are no posts on how this can be done (tools, pipelines...).

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