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Calling CNVs from WGS data

Hi all,

I want to do some whole-genome sequencing to validate CNVs and identify breakpoints for CNVs call by array data. I've been having a bit of a look around but I can't seem to find a consensus on the depth required to call CNVs accurately. Does anyone have any experience or advice on this?

cnv sv wgs sequencing
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updated by Ram Ram • written by CH • CH

1 answer

It depends on the resolution that you need, but I've called CNVs (fairly large scale) from 1x coverage or less. If you need exact breakpoints, you'll probably need substantially more.

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written by Chris Miller Chris Miller

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