what is gc bias?
Hi people! What exactly we can say about GC bias in sequencing/mapping? how can we understand it?
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Friederike
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cilgaiscan •
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cilgaiscan •
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Assuming you're referring to PCR-based sequencing, see Benjamini & Speed
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Hi cilgaiscan, what exactly do you want to know? Did you search for information? There is a huge body of work, both formal - like papers - and "informal" - like foruns and blog posts. Some links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053816/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639258/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378858/
http://seqanswers.com/forums/showthread.php?t=16114
This sounds a bit like an assignment/homework question - is it?
a badly posed one, though ;)