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how to do normalization across variable kinds of tumors

I am now studying a mRNA predictor for immune-check point inhibitor response across different kinds of tumors.When I get the different batches of patients data(RNA-seq count of patients with PD-1 response of different kinds of tumors),how should I normalized all the data that will enable me to build a model which include a set of genes to predict the response?

normalization across variable kinds of tumors

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