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Protein classification system

Hi friends, There are several protein classification systems, each of them useful in a way! I want to study the thermophilic adaption of an organism at protein sequence & structure level (SEQUENCE & structure COMPARISON). Which of the available "protein groupings" could give better insights? I presume COG classification might be better! Or is it better to select certain type of proteins alone & finish the analysis? Any other suggestions for this study are welcome! If my question is not clear please inform me! Thanks!

cog protein_classification extremophiles
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updated by c.chakraborty c.chakraborty • written by Raghul Raghul

1 answer

Well your study is quite wide. Because, I am not sure you will find something, say motif or domain absolutely common to all proteins. You can pick a class, say polymerases, membrane proteins, metabolic pathway enzymes, and then study their topology, abundance and functional motifs. This way it would be easy, and feasible to assess.

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written by c.chakraborty c.chakraborty

Thanks for the answer, This is what I am trying to do now! I am selecting enzymes,membrane proteins & proteins with hits to PDB.

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written by Raghul Raghul

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