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What are gene prediction methods with high sensitivity?

Say I want to find as many protein coding genes as possible. I have valid verification approaches (whether a predicted gene is actually translated in some cell line). Thus I would want a gene prediction tool that can find as many candidates as possible, and high false positive rate is actually more desirable than low false positive rate (or: some confidence criteria can be relaxed to achieve this). Also I would prefer de novo prediction than those that need huge training dataset. Can someone name suitable tools? Thanks!

genome gene alignment sequencing

Genes (and gene prediction tools) are very different across the different domains of life. What is your organism?

If you don't care about false positive rate could you do 6 frame translations and find all ORFs?

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